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___________基于復(fù)雜網(wǎng)絡(luò)的高血壓患者心率變異性分析_________

Heart rate variability analysis of hypertension patient based on complex network

作者:               郭艷平  侯鳳貞          
單位:           南京航空航天大學金城學院(南京211156)    
關(guān)鍵詞:           心血管系統(tǒng);復(fù)雜網(wǎng)絡(luò);非線性動力學;高血壓;心率變異性      
分類號:           R318.04    
出版年·卷·期(頁碼):2016·35·3(272-276)
摘要:

目的 利用基于復(fù)雜網(wǎng)絡(luò)理論的心率變異性(heart rate variability,HRV)分析方法來探索高血壓所致的心搏動力學變化,為評估高血壓患者的心血管系統(tǒng)功能提供新思路。方法 分析了來自于中國人民解放軍第414醫(yī)院的17例原發(fā)性高血壓患者以及17例健康老年人的HRV數(shù)據(jù):首先利用相空間重構(gòu)、內(nèi)組合排列和替代數(shù)據(jù)方法將高血壓患者組和健康對照組的極短時心率變異性序列(50點)從時間域轉(zhuǎn)換至網(wǎng)絡(luò)域,然后分析網(wǎng)絡(luò)拓撲特性,計算了4個基本的網(wǎng)絡(luò)特征參數(shù),即效率、聚類系數(shù)、平均度和度分布熵。結(jié)果 高血壓組的3個網(wǎng)絡(luò)特征參數(shù),即效率、平均度、度分布熵的值相比對照組存在著顯著下降(P<0.05),其中尤以度分布熵參數(shù)最為明顯;聚類系數(shù)相比對照組存在著接近顯著的下降(P=0.055)。結(jié)論 高血壓患者的心跳動力系統(tǒng)可能發(fā)生了兩個改變:一是既可以整體協(xié)作又能局部專注的經(jīng)濟型工作模式遭到破壞;二是在不同時刻之間的非線性耦合性減弱。

Objective We adopt heart rate variability (HRV) analysis method based on complex network theory to explore the variability of heartbeat kinetic caused by hypertension,which provides new thoughts to evaluate the cardiovascular system function for hypertensive patients.Methods This paper analyzes the HRV data from 17 cases of primary hypertension patients (from the 414th Hospital of Chinese People’s Liberation Army) and 17 cases of healthy older people.Firstly,by adopting phase space reconstruction,internal combined arrangement and surrogate data method,the very short-term heart rate variability sequence (50 points) of hypertension patients group and healthy control group are converted from time domain to network domain.Then we analyze the topological characteristic of network,and calculate the four fundamental network characteristic parameters: efficiency,clustering coefficient,average degrees and distribution entropy value.Results Three network character parameters of hypertension group,namely efficiency,average degree and distribution entropy values,significantly decrease in comparison with the healthy control group (P<0.05),especially for the distribution entropy parameter.The decrease of clustering coefficient in hypertension group is close to significant in comparison with the healthy control group (P=0.055).Conclusions Two changes may occur for the heartbeat dynamic systems of hypertensive patients: one is that the economic operation mode,which allows system both in overall collaboration and local focus,is destroyed;second is that the nonlinear and coupling of system at different times is weakened.

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