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經(jīng)顱磁刺激中刺激線圈的仿真研究

Simulationstudy on coils for transcranial magnetic stimulation

作者: 周亞男  張紅衛(wèi)  郝冬梅  曹镠  榮瑤 
單位:北京工業(yè)大學(xué)生命科學(xué)與生物工程學(xué)院(北京100124)
關(guān)鍵詞: 經(jīng)顱磁刺激;線圈;電場分布;真實(shí)頭部模型;SEMCAD  X 
分類號:R318.04
出版年·卷·期(頁碼):2016·35·4(360-366)
摘要:

目的 設(shè)計(jì)用于經(jīng)顱磁刺激的線圈,要求能夠?qū)Υ竽X皮質(zhì)進(jìn)行多點(diǎn)刺激,且具有聚焦性好、制作簡單、使用方便等特點(diǎn)。方法 利用電磁仿真方法,以圓形線圈和8字形線圈為基礎(chǔ),計(jì)算線圈在均勻人體模型中感應(yīng)電場的分布情況,比較尺寸、繞法對經(jīng)顱磁刺激線圈的聚焦性和刺激深度的影響。在此基礎(chǔ)上設(shè)計(jì)了一種多圓相切線圈,并計(jì)算該線圈在均勻人體和真實(shí)頭部模型中的電場分布。結(jié)果 感應(yīng)電場強(qiáng)度隨刺激深度的增加呈指數(shù)式衰減。減小圓形線圈的尺寸,會(huì)提高聚焦性,同時(shí)可減弱感應(yīng)電場強(qiáng)度。8字形線圈比圓形線圈具有更好的聚焦性,多層繞法綜合效果較好。多圓相切線圈具有8字形線圈的優(yōu)點(diǎn),且可以進(jìn)行多點(diǎn)刺激。結(jié)論 尺寸、繞法等因素對線圈的聚焦性和刺激深度具有重要影響,多圓相切線圈在經(jīng)顱磁刺激中具有很好的應(yīng)用前景。真實(shí)頭部模型仿真,對于線圈的設(shè)計(jì)和靶區(qū)定位具有重要意義。

Objective To design a new type of coil for transcranial magnetic stimulation (TMS),which can stimulate the cerebral cortex on multipoint with good focusing property and is simple to make and convenient to use. Methods Circular coils and figure-8 coils were simulated using electromagnetic simulation methods. The distribution of the coil-induced electric field in homogeneous phantom was computed. The impact of coil size and winding on the focusability and stimulation depth of TMS coils were analyzed. On this basis,a new type of coil named multi-circle tangent coil (MTC) was designed,and the distribution of MTC-induced electric field in homogeneous phantom model and realistic human head model was computed. Results With the increase of stimulation depth,there was an exponential decay in the intensity of the induced electric field. Smaller circular coils produced higher focusability and lower intensity of induced electric field. The focusability of figure-8 coils was higher than that of circular coils. The comprehensive effect of multi-layer winding method was preferable. MTC supported multipoint stimulation in addition to owning the advantages of figure-8 coils. Conclusions Factors such as size and winding have a big influence on the focusability and stimulation depth of coils. MTC has an exciting application prospect in TMS. Simulation on realistic human head model is of great significance for coil design and target location. 

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