北京生物醫(yī)學工程

一氧化碳吸入裝置的設(shè)計與實現(xiàn)

Design and implementation of carbon monoxide inhalation device

作者：趙柏淦胡兆燕陳正龍

單位：上海理工大學機械工程學院(上海200093)

分類號：R318.6

出版年·卷·期（頁碼）：2016·35·5（503-509）

摘要：

目的一氧化碳(carbon monoxide, CO)是一種重要的內(nèi)源性介質(zhì)，可用于治療新生兒持續(xù)肺動脈高壓、急性肺損傷等嚴重疾病。但目前有關(guān)一氧化碳吸入裝置的報道較少，因此本文設(shè)計并實現(xiàn)了一種與呼吸機聯(lián)用的一氧化碳吸入裝置以滿足臨床需求。方法通過氣體稀釋公式計算出在治療條件下CO標氣的流量，并由轉(zhuǎn)子流量計控制CO標氣送入呼吸回路，采用CO電化學傳感器對進入患者前的治療氣中CO濃度進行檢測，具有實時監(jiān)測、顯示濃度、超標聲光報警等功能，并與呼吸機聯(lián)用后檢驗了該裝置的示值誤差和響應時間。結(jié)果該裝置的示值誤差為2.2%，響應時間平均為23.5s，能滿足臨床實驗的需求。結(jié)論本文所研發(fā)的與呼吸機聯(lián)用吸入裝置的濃度監(jiān)測范圍、輸出流量、響應時間及顯示精度等技術(shù)參數(shù)滿足預期的設(shè)計要求。

Objectives Carbon monoxide (CO) is an important endogenous medium, which can be used in the treatment of persistent pulmonary hypertension of the newborn, acute lung injury and other serious diseases. In view of report of the CO inhalation device is rare, a carbon monoxide inhalation device cooperated with the ventilator is introduced in this paper. Methods This device works out the flow value of CO on the therapeutic condition using the formula of gas dilution. Then its rotor flow meter controls the flow of CO and delivers it to the respiratory circuit. At the same time, the concentrations of CO are detected by the electrochemical CO sensors before the therapeutic gas enters into the patient. It can realize the function of real-time monitoring, dynamic display of concentration, sound and light alarm and so on. The indication error and response time of the device are tested after connected with the ventilator. Results The experiment with the ventilator shows that this device’s indication error is 2.2% and response time is 23.5s, which can meet the requirements of clinical experiment. Conclusions The device’s technical parameters such as concentration monitoring range, output flow, response time and display accuracy meet the expected design requirements.

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