北京生物醫(yī)學(xué)工程

基于案例推理在艾滋病患者個(gè)性化治療方案推薦中的應(yīng)用

Application of case-based reasoning on personalized treatment for AIDS patients

作者：陳婕卿楊秋英陳卉黃曉婕

單位：首都醫(yī)科大學(xué)生物醫(yī)學(xué)工程學(xué)院（北京100069）

關(guān)鍵詞：基于案例推理；聚類分析；患者相似性；數(shù)據(jù)可視化；艾滋病

分類號(hào)：R318.04;TP311;TN911.73

出版年·卷·期（頁(yè)碼）：2017·36·1（16-20）

摘要：

目的探討艾滋病患者相似性與抗病毒治療方案之間的關(guān)系，為制定艾滋病患者個(gè)性化治療方案提供依據(jù)。方法收集首次接受抗病毒治療且治療后免疫重建良好的648例艾滋病患者臨床資料，計(jì)算基于歐氏距離的患者相似性，以最相似的前10%患者治療方案作為推薦方案，實(shí)現(xiàn)基于案例推理的治療方案推薦，并通過(guò)數(shù)據(jù)可視化工具呈現(xiàn)基于案例推理和聚類分析的結(jié)果。結(jié)果基于患者相似性推薦的治療方案與實(shí)際初始治療方案的一致率達(dá)到83.3%。結(jié)論根據(jù)患者相似性推薦的治療方案與實(shí)際的治療方案之間具有較高的一致性，證實(shí)了基于案例推理和聚類分析在艾滋病患者個(gè)性化治療方案推薦中的可行性和有效性，為艾滋病領(lǐng)域的精準(zhǔn)醫(yī)療研究提供了參考。

Objective To investigate the relationship between the similarity of AIDS patients and their antiviral treatment regimens in order to provide reference to the personalized treatment for AIDS patients. Methods Clinical data of 648 AIDS patients who received highly active antiretroviral therapy with good immune reconstruction were collected. Patient similarity was calculated based on Euclidean distance. The most adopted treatment regimen among the top 10% most similar patients was regarded as the recommended regimen. Results of case-based reasoning and cluster analysis were presented by data visualization tools. Results Treatment regimens recommended on the basis of patient similarities had up to 83.3% agreement with the initial treatment regimens in practice. Conclusions Recommended treatment regimens based on the patient similarities were highly consistent with the actual regimens，confirming the feasibility and effectiveness of the case-based reasoning and cluster analysis in the personalized treatment for AIDS patients，which provided a way for the further precision medicine for AIDS patients.

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